Renal Denervation in Heart Failure: A New Therapeutic Paradigm
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چکیده
منابع مشابه
Renal Denervation in Heart Failure: A New Therapeutic Paradigm
Heart failure constitutes a significant source of morbidity and mortality in the United States, and its incidence and prevalence continue to grow, increasing its burden on the health care system. Renal dysfunction in patients with heart failure is common and has been associated with adverse clinical outcomes. This complex interaction is characterized by a pathophysiological disequilibrium betwe...
متن کاملTherapeutic effects of renal denervation on renal failure.
Sympathetic nerve activity (SNA) is increased in both patients and experimental animals with renal failure. The kidney is a richly innervated organ and has both efferent and afferent nerves. Renal denervation shows protective effects against renal failure in both animals and humans. The underlying mechanisms include a decrease in blood pressure, a decrease in renal efferent SNA, a decrease in c...
متن کاملRenal Denervation for Chronic Heart Failure: Background and Pathophysiological Rationale
The activation of the sympathetic nervous system is associated with cardiovascular hospitalizations and death in heart failure. Renal denervation has been shown to effectively reduce sympathetic overdrive in certain patients with uncontrolled hypertension. Pilot trials investigating renal denervation as a potential treatment approach for heart failure were initiated. Heart failure comorbidities...
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Heart failure (HF) is a syndrome whose cardinal symptoms are dyspnea and fatigue leading to a progressive decrease in exercise capacity. Drugs currently used include angiotensin-converting-enzyme inhibitors, angiotensin receptor blockers (ARB), diuretics, alone or in combination, and in the cases where indicated, digoxin. Sacubitril/valsartan represents a new approach to treatment since the dru...
متن کاملRenal denervation modulates angiotensin receptor expression in the renal cortex of rabbits with chronic heart failure.
Excessive sympathetic drive is a hallmark of chronic heart failure (HF). Disease progression can be correlated with plasma norepinephrine concentration. Renal function is also correlated with disease progression and prognosis. Because both the renal nerves and renin-angiotensin II system are activated in chronic HF we hypothesized that excessive renal sympathetic nerve activity decreases renal ...
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ژورنال
عنوان ژورنال: Clinical Medicine Insights: Cardiology
سال: 2015
ISSN: 1179-5468,1179-5468
DOI: 10.4137/cmc.s18754